None applicable
ELUCIDATION OF THE PATHOMECHANISM OF HYPERTENSION, HEART FAILURE, ATHEROSCLEROSIS AND DIABETIC VASCULAR DISEASE AND SEARCH FOR THERAPEUTIC AGENTS: A CARDIOVASCULAR BIOLOGICAL STUDY THE ROLE OF NOVEL ADIPOSE TISSUE-DERIVED CYTOKINES (ADIPOCYTOKINES) IN THE CARDIOVASCULAR SYSTEM STUDIES ON THE RELATIONSHIP BETWEEN CARDIAC REMODELING AND EXTRACELLULAR MATRIX DEGRADATION PRODUCTS. EFFECTS OF BIOACTIVE FACTORS AND DRUGS ON CARDIAC AND VASCULAR REACTIVITY AND ION CHANNEL CURRENTS THE ROLE OF EXTRACELLULAR VESICLES (EVS) IN THE CARDIOVASCULAR SYSTEM.
(Awards) Kitasato Research Institute 17th Morimura Toyomei-kai Incentive Award (2019) The 162nd Annual Meeting of the Japanese Society of Veterinary Science Incentive Award of the Society of Comparative Pharmacology and Toxicology (2019) The 33rd Academic Encouragement Award of the Japanese Pharmacological Society (2018) Japanese Society of Veterinary Science Incentive Award for Veterinary Science 2017-2018 Japanese Society of Veterinary Science 2016-2017 Veterinary Science Encouragement Award Japanese Society of Veterinary Science 2015-2016 Veterinary Science Encouragement Award
(2020年)
1. Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, and Yamawaki H. Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. Pflugers Archiv - Eur J Physiol, 2020. In Press.
2. Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M, and Yamawaki H. Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflugers Archiv - Eur J Physiol 472: 335-342, 2020.
3. Sugiyama A, Okada M, and Yamawaki H. Canstatin suppresses isoproterenol-induced cardiac hypertrophy through inhibition of calcineurin/nuclear factor of activated T-cells pathway in rats. Eur J Pharmacol 871: 172849, 2020.
(2019年)
1. Otani K, Fujioka Y, Okada M, and Yamawaki H. Optimal isolation method of small extracellular vesicles from rat plasma. Int J Mol Sci 20: 4780, 2019.
2. Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts. Apoptosis 24: 359-368, 2019.
3. Imoto K, Okada M, and Yamawaki H. Periostin mediates right ventricular failure through induction of inducible nitric oxide synthase expression in right ventricular fibroblasts from monocrotaline-induced pulmonary arterial hypertensive rats. Int J Mol Sci 20: 62, 2019.
(2018年)
1. Otani K, Yokoya M, Kodama T, Hori K, Matsumoto K, Okada M, and Yamawaki H. Plasma exosomes regulate systemic blood pressure in rats. Biochem Biophys Res Commun 503: 776-783, 2018.
2. Imoto K, Okada M, and Yamawaki H. Characterization of fibroblasts from hypertrophied right ventricle of pulmonary hypertensive rats. Pflugers Archiv - Eur J Physiol 470: 1405-1417, 2018.
3. Kodama T, Okada M, and Yamawaki H. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci 137: 86-92, 2018.
4. Sugiyama A, Hirano Y, Okada M, and Yamawaki H. Endostatin stimulates proliferation and migration of myofibroblasts isolated from myocardial infarction model rats. Int J Mol Sci 19: 741, 2018.
(2017年)
1. Sugiyama A, Okada M, and Yamawaki H. Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats. Eur J Pharmacol 807: 32-43, 2017.
2. Yasuda J, Okada M, and Yamawaki H. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts. Eur J Pharmacol 807: 64-70, 2017.
3. Okada M, Murata N and Yamawaki H. Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2. Am J Physiol-Cell Physiol 312: C199-C208, 2017.
(2016年)
1. Okada M, Morioka S, Kanazawa H, and Yamawaki H. Canstatin inhibits isoproterenol-induced apoptosis through preserving mitochondrial morphology in differentiated H9c2 cardiomyoblasts. Apoptosis 21: 887-895, 2016.
2. Kameshima S, Sakamoto Y, Okada M, and Yamawaki H. Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats. Acta Physiol (Oxf) 217: 120-129, 2016.
3.Imoto K, Kumatani S, Okada M, and Yamawaki H. Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel . Pflugers Archiv - Eur J Physiol 468: 1259-1270, 2016.
(2015年)
1. Kunimoto H, Kazama K, Takai M, Oda M, Okada M, and Yamawaki H. Chemerin promotes proliferation and migration of vascular smooth muscle and increases mouse blood pressure. Am J Physiol-Heart and Circulatory Physiology 309: H1017-H1028, 2015.
2. Kameshima S, Kazama K, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol-Heart and Circulatory Physiology 308: H1298-H1305, 2015.
3. Kazama K, Okada M, and Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species. Biochem Biophys Res Commun 457: 602-607, 2015.
4. Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiol (Oxf) 213: 472-480, 2015.
BUILDING A, 5TH FLOOR
