None applicable
1. Basic and clinical research on uveitis, cataract and glaucoma 2.Basic and Clinical Research on Corneal Regeneration 3．Basic research on organ regeneration
Topics in the last 5 years (1) About our lab members Mr. Yuya Otaka joined our laboratory as a graduate student in April 2020. Mr. Kazuaki Sato graduated from the graduate school in March 2019 and obtained Doctor of Veterinary Medicine. Mr. Mizuki Kita joined our lab as a graduate student in April 2018. As of April 2020, the laboratory consists of 2 faculty members, 2 graduate students, 1 research student and 12 undergraduate students. (2) Awards In 2019, Mr. Mizuki Kita, a graduate student, received an award for encouragement at the Tohoku Regional Veterinary Medical Association Meeting for his presentation entitled "A study on the healing rate of idiopathic chronic corneal epithelial defects in dogs after repeated epithelial debridement with sterile cotton swabs". In 2018, Dr. Kazuki Tajima received the Academic Encouragement Award from Animaru Smile, Inc. for his presentation entitled "Inhibition of TNF-α production and macrophage migration in conjunctiva by rebamipide". Dr. Yohei Yamashita (Ebisu Veterinary Hospital, Sendai City, Miyagi Prefecture, Japan), a research student of our laboratory, received the President's Award at the Tohoku Regional Veterinary Medical Association Meeting in 2017 for his presentation entitled "A case of a dog undergoing vitrectomy for cleft retinal detachment with damage to the posterior capsule". Dr. Marika Fukui (NOSAI, Aomori Livestock Clinic), a research student of our laboratory, won the NOSAI Tohoku Regional Conference Award in 2017 for her presentation entitled "A case of newborn calf with Dandy-Walker Syndrome-like deformity". In 2017, Kazuaki Sato, a graduate student, received a grant from Sasakawa Science Research Grant for his research project "Elucidation of the pathogenesis of experimental canine uveitis by searching for novel inflammatory mediators in aqueous humor". In 2016, Dr. Kazuki Tajima received the Research Encouragement Award from Keio University School of Medicine for his research project "Establishment of a new in situ liver regeneration method using autologous organ skeleton". Dr. Kazuki Tajima received the Alumni Award from the Department of Ophthalmology, Tokyo Medical University in 2016. Dr. Kazuki Tajima won the Best Poster Award (Uchida Award) at the Japanese Society of Keratology in 2016 for his presentation entitled "Pathogenicity analysis of multidrug-resistant Pseudomonas aeruginosa by comprehensive search of pathogenic genes". (3) Special lecture In 2020, Dr. Kazuki Tajima gave an invited lecture at the Japanese Society for Veterinary Regenerative Medicine with the title "Application of Regenerative Medicine Technology in Veterinary Ophthalmology and its Future". In 2019, Dr. Kazuki Tajima will deliver an invited lecture at the Japanese Society for Regenerative Medicine, entitled "One in three cats has renal failure - a challenge to kidney regeneration using decellularized organ skeletons". In 2018, Dr. Kazutaka Kanai gave an invited lecture at the Japan Veterinary Ophthalmology Conference on "New treatment for uveitis".
直近20報 (2020.4-)
＜2020＞
・Minami M, Seiriki R, Otake H, Nakazawa Y, Kanai K, Tanino T and Nagai N. 2020. Development of sustained-release ophthalmic formulation based on tranilast solid nanoparticles. Materials (Basel). 2020 Apr 3;13(7):1675.
・Tajima K, Kuroda K, Otaka Y, Kinoshita R, Kita M, Oyamada T and Kanai K. 2020. Decellularization of canine kidney for three-dimensional organ regeneration.Vet World. Mar;13(3):452-457.
・Nagai N, Ishii M, Seiriki R, Ogata F, Otake H, Nakazawa Y, Okamoto N, Kanai K and Kawasaki N. 2020. Novel sustained-release drug delivery system for dry eye therapy by rebamipide nanoparticles. Pharmaceutics. Feb 14;12(2):155.
・喜多瑞樹、金井一享、能美君人、佐藤和昭、山下洋平、田島一樹. 2020. 結膜扁平上皮癌の摘出後に角膜および結膜への腫瘍播種が疑われた症例をマイトマイシンCの点眼処置と凍結処置で治療した犬の1例. 動物臨床医学.
＜2019＞
・Sato K, Iwasaki K, Nagai N, Yamashita Y, Chikazawa S, Hoshi F and Kanai K. 2019. Comparison of early posttreatment effects of two steroidal anti-inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes. Vet Ophthalmol. Sep;22(5):607-613.
・Shimoda H, Yagi H, Higashi H, Tajima K, Kuroda K, Abe Y, Kitago M, Shinoda M, Kitagawa Y. 2019. Decellularized liver scaffolds promote liver regeneration after partial hepatectomy. Sci Rep. Aug 29;9(1):12543.
・Wakabayashi T, Yagi H, Tajima K, Kuroda K, Shinoda M, Kitago M, Abe Y, Oshima G,Hirukawa K, Itano O, Kitagawa Y. 2019. Efficacy of New Polylactic Acid Nonwoven Fabric as a Hemostatic Agent in a Rat Liver Resection Model. Surg Innov. Jun 26(3):312-320.
・Nagai N, Iwai Y, Deguchi S, Otake H, Kanai K, Okamoto N and Shimomura Y. Therapeutic Potential of a Combination of Magnesium Hydroxide Nanoparticles and Sericin for Epithelial Corneal Wound Healing. Nanomaterials (Basel). May 19;9(5):768.
・Sato K, Kanai K, Ozaki M, Kagawa T, Kita M, Yamashita Y, Nagai N and Tajima K. 2019. Preventive effects of tyrosol, a natural phenolic compound, on anterior uveitis induced by anterior chamber paracentesis in healthy beagle dogs. J Vet Med Sci. Apr 16;81(4):573-576.
・Narimatsu A, Hattori T, Koike N, Tajima K, Nakagawa H, Yamakawa N, Usui Y, Kumakura S, Matsumoto T and Goto H. 2019. Corneal lymphangiogenesis ameliorates corneal inflammation and edema in late stage of bacterial keratitis. Sci Rep. Feb 27;9(1):2984.
＜2018＞
・Watanabe M, Yano K, Okawa K, Yamashita T, Tajima K, Sawada K, Yagi H, Kitagawa Y, Tanishita K and Sudo R. 2018. Construction of sinusoid-scale microvessels in perfusion culture of a decellularized liver. Acta Biomater. Dec 26. S1742-7061(18)30767-0.
・Inomata K※, Tajima K※, Yagi H, Higashi H, Shimoda H, Matsubara K, Hibi T, Abe Y, Tsujikawa H, Kitago M, Shinoda M, Obara H, Itano O, Soto-Gutierrez A and Kitagawa Y. 2018. A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus. Sci Rep. Oct 9;8(1):14987. ; ※Equally contribute.
・Tajima K, Yagi H and Kitagawa Y. 2018. Human-Scale Liver Harvest and Decellularization for Preclinical Research. Methods Mol Biol. Sep 6 1577:327-335.
・Nagai N., Yamaoka S., Fukuoka Y., Ishii M., Otake H., Kanai K., Okamoto N. and Shimomura Y. 2018. Enhancement in corneal permeability of dissolved carteolol by its combination with magnesium hydroxide nanoparticles. Int J Mol Sci. Jan 17;19(1):282.
＜2017＞
・Nagai N., Ogata F., Otake H., Kawasaki N., Nakazawa Y., Kanai K., Okamoto N. and Shimomura Y. 2017. Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol. Exp Eye Res. Dec;165:118-124.
・Tajima K, Hattori T, Takahashi H, Katahira H, Narimatsu A, Kumakura S, Goto H. 2017. Rebamipide suppresses TNF-α production and macrophage infiltration in the conjunctiva. Vet Ophthalmol. 2018 Jul;21(4):347-352.
・Takagi C, Yagi H, Hieda M, Tajima K, Hibi T, Abe Y, Kitago M, Shinoda M, Itano O, Kitagawa Y. 2017. Mesenchymal Stem Cells Contribute to Hepatic Maturation of Human Induced Pluripotent Stem Cells. Eur Surg Res. 58(1-2):27-39.
・Nagai N, Nakazawa Y, Ito Y, Kanai K, Okamoto N, Shimomura Y. 2017. A Nanoparticle-Based Ophthalmic Formulation of Dexamethasone Enhances Corneal Permeability of the Drug and Prolongs Its Corneal Residence Time. Biol Pharm Bull. 40(7):1055-1062.
<2016>
・ Sato K, Mihara Y, Kanai K, Yamashita Y, Kimura Y and Itoh N. 2016. Relative potency of tyrosol in the treatment of endotoxin-induced uveitis in rats. J Vet Med Sci. Nov 1;78(10):1631-1634.
・Katsuki Y, Yagi H, Okitsu T, Kitago M, Tajima K, Kadota Y, Hibi T, Abe Y, Shinoda M, Itano O, Takeuchi S and Kitagawa Y. 2016. Endocrine pancreas engineered using porcine Islets and partial pancreatic scaffolds. Pancreatology. Sep-Oct 2016;16(5):922-930.
HALL V10, 4TH FLOOR
There are only a few universities in Japan that have teachers specialising in veterinary ophthalmology, but our laboratory is the only one in Japan with two full-time teachers specialising in veterinary ophthalmology. We are always looking for graduate students and research students. Please contact us if you are interested in research or would like to become a veterinary ophthalmologist.
